Genes & Cancer

Volume 5: Issue 9-10, September 2014

pp303-374

Issue 9-10, September 2014

About the Cover

The cover for Genes & Cancer features figure 9E ("TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer") from Singha et al.

Research Perspective

Cutting the brakes and flooring the gas: how TMEPAI turns TGF-β into a tumor promoter

https://doi.org/10.18632/genesandcancer.34

Magdalena A. Cichon, and Derek C. Radisky

p 303-305

Abstract |  PDF |  Full Text

Research Papers

Telomere dysfunction suppresses multiple endocrine neoplasia in mice

https://doi.org/10.18632/genesandcancer.31

Ji-Hyeon Lee, Miriam Anver, Maria Kost-Alimova, Alexei Protopopov, Ronald A. DePinho, and Sushil G. Rane

p 306-319

Abstract |  PDF |  Full Text

TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer

https://doi.org/10.18632/genesandcancer.30

Prajjal K. Singha, Srilakshmi Pandeswara, Hui Geng, Rongpei Lan, Manjeri A. Venkatachalam, and Pothana Saikumar

p 320-336

Abstract |  PDF |  Full Text |  Supplementary Materials

Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells

https://doi.org/10.18632/genesandcancer.29

Xiaobing Deng, and Eileen Friedman

p 337-347

Abstract |  PDF |  Full Text |  Supplementary Materials

Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption

https://doi.org/10.18632/genesandcancer.32

Nina M. Muñoz, Lior H. Katz, Ji-Hyun Shin, Young Jin Gi, Vipin Kumar Menon, Mihai Gagea, Asif Rashid, Jian Chen, and Lopa Mishra

p 348-352

Abstract |  PDF |  Full Text

miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling

https://doi.org/10.18632/genesandcancer.33

Elizabeth C. Martin, Adrienne E. Krebs, Hope E. Burks, Steven Elliott, Melody Baddoo, Bridgette M. Collins-Burow, Erik K. Flemington, and Matthew E. Burow

p 353-364

Abstract |  PDF |  Full Text

The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms

https://doi.org/10.18632/genesandcancer.28

Tanja Haag, Christina E. Herkt, Sara K. Walesch, Antje M. Richter, and Reinhard H. Dammann

p 365-374

Abstract |  PDF |  Full Text