Alcohol, stem cells and cancer
Shoujun Gu1, Bao-Ngoc Nguyen1, Shuyun Rao1, Shulin Li2, Kirti Shetty3, Asif Rashid4, Vivek Shukla5, Chu-Xia Deng1,6, Lopa Mishra1,7 and Bibhuti Mishra1
1 Department of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA
2 Departments of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
3 Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
4 Departments of Gastroenterology and Liver Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
5 Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
6 Faculty of Health Sciences, University of Macau, Macau SAR, China
7 Surgical Service, Veterans Affairs Medical Center, Washington DC, USA
Correspondence:
Bibhuti Mishra, email:
Correspondence:
Lopa Mishra, email:
Correspondence:
Chu-Xia Deng, email:
Keywords: alcohol; cancer; stem cells; TGF-β; DNA repair
Received: September 19, 2017 Accepted: October 17, 2017 Published: November 11, 2017
Abstract
Dosage, gender, and genetic susceptibility to the effects of alcohol remained only partially elucidated. In this review, we summarize the current knowledge of the mechanisms underlying the role of alcohol in liver and gastrointestinal cancers. In addition, two recent pathways- DNA repair and TGF-β signaling which provide new insights into alcohol in the regulation of cancers and stem cells are also discussed here.
